Budget impact analysis second class reimbursement submission of injectable long-acting schizophrenia maintenance treatment drug in Belgium.

07 juni 2019

Lundbeck asked Hict for support in developing a budget impact analysis (BIA) for the reimbursement submission of Abilify Maintena®, a long-acting injectable drug for the maintenance treatment of schizophrenia.

Expertise: Health Economics

Project Highlights

  • Customer: Lundbeck
  • Main Goal: Provide support on the price strategy and develop a BIA for the Belgian reimbursement submission
  • Main Result: reimbursement of Abilify Maintena® for the maintenance treatment of schizophrenia

The aim of the project for Hict was to provide support for the BIA and the price strategy.

In an intake phase, Hict determined the general strategy and the key elements of the BIA: identification of

  • correct comparators
  • different product values to include in the BIA
  • requested clinical, epidemiological and cost data for the BIA
  • current available sources for clinical data, epidemiological data & cost data
  • possible price strategies

In the subsequent phase, Hict was responsible for

  • data collection & processing of this data
  • development of the BIA model
  • population of the model with the collected data
  • development of a report detailing the BIA and its results


In the intake phase, based on desk research and literature search, the most appropriate approach and strategy for the BIA in the reimbursement dossier of Abilify Maintena® was defined in cooperation with Lundbeck.

Second, the necessary data collection & processing was done based on desk research. An analysis of the reimbursement criteria of the comparators and existing market researches was performed, together with research on Belgian prevalence data, resource use and unit costs.

Subsequently, the BIA model was developed and populated with the collected Belgian data. A validation of the generated results was performed internally and with Lundbeck.

Finally, an extensive report was written, discussing in detail all aspects of the BIA model, together with the used data, values and sources. The report and the detailed BIA model was delivered and presented to Lundbeck.


  • Quantification of all necessary model parameters based on data analysis and literature research;
  • BIA model populated with collected Belgian data (including one-way sensitivity analysis);
  • Detailed report on the model and their final results.