Exploring Applications of Polygenic Risk Scores in Alzheimer's Disease

Alzheimer's Disease (AD) is the most common form of dementia, affecting 1 in 10 people above 65 years old and 1 in 2 people above 85 years old.

Expertise Pillar: Value, HEMAR.

Hict is a consortium partner in the PRISMA project, where researchers are developing a polygenic risk score (PRS) to measure disease risk due to genetic predisposition. However, genetic predisposition only accounts for about 70% of AD cases, making it unclear if the PRS's predictability is sufficient for clinical diagnosis. This project aims to identify potential applications where PRS can provide added value, such as estimating the rate of disease progression.

As an intern at Hict, you'll explore these possible applications of PRS in Alzheimer's Disease, based on available literature and interviews with PRISMA consortium partners.


  • We're seeking proactive Master's students (ongoing or recent graduates) with a strong interest in healthcare systems.
  • Required skills: literature and database research, qualitative analysis, interviews, SWOT analysis.
  • Relevant interests: Alzheimer's Disease, genetics, predictive value, market analysis, implications for clinical practice.


  • Delve into the field of genetic risk scores and Alzheimer's Disease, considering the perspectives of various stakeholders.
  • Acquire valuable job market insights to help you navigate your career path as a young graduate.
  • Join a team of skilled consultants in a dynamic, project-driven work environment. In addition to your specific intern project, you may be involved in other ongoing projects or internal processes, offering a glimpse into various consultant roles.


We will be giving an online info session on the different internship topics in the week of 24 April 2023.

Register by submitting this registration form.

If you are already convinced, or you wish to contact us directly you can send an email to intern@hict.com. We will put you in contact with the right person.

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Check out our internship page for other topics you could be working on.

If you have any questions regarding internships, email us at intern@hict.com.